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National Cancer Institute Thesaurus
| Preferred Name | Busulfan | |
| Synonyms |
Tetramethylene Bis(methanesulfonate) 1,4-Butanediol Dimethylsulfonate Tetramethylene bis[methanesulfonate] Methanesulfonic Acid Tetramethylene Ester 1,4-Di(methylsulfonyloxy)butane Myeloleukon Methanesulfonic acid, tetramethylene ester 1, 4-Bis[methanesulfonoxy]butane 1,4-Di(methanesulfonyloxy)butane 1,4-Bis(methanesulfonoxy)butane 1,4-Bitanediol Dimethanesulfonate Esters BUS BUSULFAN Busilvex Bussulfam Busulfan Busulfanum Busulfex Busulphan CB 2041 CB-2041 GT 41 GT-41 Glyzophrol Joacamine Mielucin Misulban Misulfan Mitosan Myeleukon Myelosan Mylecytan Myleran Sulfabutin WR-19508 busulfan |
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| Definitions |
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C321 |
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| Accepted_Therapeutic_Use_For |
Bone marrow disorders; chronic myelogenous leukemia; palliative; neoadjuvant to allogeneic hematopoietic progenitor cell transplantation; neoplastic meningitis; primary brain malignancies
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents.
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|
| CAS_Registry |
55-98-1
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|
| CHEBI_ID |
CHEBI:28901
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|
| Chemical_Formula |
C6H14O6S2
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|
| code |
C321
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
CTRP FDA GDC HemOnc PCDC
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|
| DEFINITION |
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)
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|
| Display_Name |
Busulfan
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|
| FDA_UNII_Code |
G1LN9045DK
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|
| FULL_SYN |
Tetramethylene Bis(methanesulfonate) 1,4-Butanediol Dimethylsulfonate Tetramethylene bis[methanesulfonate] Methanesulfonic Acid Tetramethylene Ester 1,4-Di(methylsulfonyloxy)butane Myeloleukon Methanesulfonic acid, tetramethylene ester 1, 4-Bis[methanesulfonoxy]butane 1,4-Di(methanesulfonyloxy)butane 1,4-Bis(methanesulfonoxy)butane 1,4-Bitanediol Dimethanesulfonate Esters BUS BUSULFAN Busilvex Bussulfam Busulfan Busulfanum Busulfex Busulphan CB 2041 CB-2041 GT 41 GT-41 Glyzophrol Joacamine Mielucin Misulban Misulfan Mitosan Myeleukon Myelosan Mylecytan Myleran Sulfabutin WR-19508 busulfan
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| Is_PCDC_AML_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Busulfan
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|
| Legacy Concept Name |
Busulfan
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|
| Maps_To |
Busulfan
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|
| NCI_Drug_Dictionary_ID |
41947
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| NSC Number |
750
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| PDQ_Closed_Trial_Search_ID |
41947
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| PDQ_Open_Trial_Search_ID |
41947
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|
| Preferred_Name |
Busulfan
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|
| prefixIRI |
Thesaurus:C321
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0006463
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| subClassOf |
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