loading...| Preferred Name |
Hepatocellular Carcinoma |
|
| Synonyms |
Hepatocellular carcinoma Hepatocellular Cancer Carcinoma of Liver Cells hepatocellular carcinoma Liver Cell Carcinoma Primary Carcinoma of the Liver Cells CARCINOMA, HEPATOCELLULAR, MALIGNANT Carcinoma of the Liver Cells Primary Carcinoma of Liver Cells Liver Cell Cancer (Hepatocellular Carcinoma) Liver cell carcinoma Hepatocellular Carcinoma HCC Hepatoma LIHC hepatoma |
|
| Definitions |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3099 |
|
| ALT_DEFINITION |
A malignant neoplasm arising from hepatocytes. A type of adenocarcinoma and the most common type of liver tumor. |
|
| code |
C3099 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138190 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157529 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168656 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77526 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88025 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156966 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168658 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193248 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193178 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193231 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193006 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138188 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158520 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193249 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156953 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168657 |
|
| Contributing_Source |
Cellosaurus CDISC CPTAC CTEP CTRP GDC mCode |
|
| DEFINITION |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
|
| Display_Name |
Hepatocellular Carcinoma |
|
| FULL_SYN |
Hepatocellular carcinoma Hepatocellular Cancer Carcinoma of Liver Cells hepatocellular carcinoma Liver Cell Carcinoma Primary Carcinoma of the Liver Cells CARCINOMA, HEPATOCELLULAR, MALIGNANT Carcinoma of the Liver Cells Primary Carcinoma of Liver Cells Liver Cell Cancer (Hepatocellular Carcinoma) Liver cell carcinoma Hepatocellular Carcinoma HCC Hepatoma LIHC hepatoma |
|
| ICD-O-3_Code |
8170/3 |
|
| Is_Value_For_GDC_Property | ||
| label |
Hepatocellular Carcinoma |
|
| Legacy Concept Name |
Hepatocellular_Carcinoma |
|
| Maps_To |
Hepatoma, malignant Malignant neoplasm: Liver cell carcinoma Hepatocarcinoma Liver cell carcinoma Hepatocellular carcinoma, NOS Hepatoma, NOS 8170/3 |
|
| Neoplasm_Has_Special_Category | ||
| Neoplastic_Status |
Malignant |
|
| Preferred_Name |
Hepatocellular Carcinoma |
|
| prefixIRI |
Thesaurus:C3099 |
|
| Semantic_Type |
Neoplastic Process |
|
| UMLS_CUI |
C0019204 |
|
| subClassOf |