National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29842
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29842
Preferred Name

Nimesulide
Definitions
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)
Synonyms
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
NIMESULIDE
Nimesulide
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Nimesulide
Legacy Concept Name
Nimesulide
CHEBI_ID
CHEBI:44445
Preferred_Name
Nimesulide
Semantic_Type
Pharmacologic Substance
prefixIRI
Thesaurus:C29842
DEFINITION
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)
UMLS_CUI
C0132515
code
C29842
Chemical_Formula
C13H12N2O5S
subClassOf
type
CAS_Registry
51803-78-2
FULL_SYN
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
NIMESULIDE
Nimesulide
FDA_UNII_Code
V4TKW1454M
Contributing_Source
FDA
Concept_In_Subset
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