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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29265
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29265
|
|---|---|
| Preferred Name | Mirtazapine |
| Definitions |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.
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| Synonyms |
MIRTAZAPINE
mirtazapine
Mirtazapine
Remeron
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Mirtazapine
|
|---|---|
| Legacy Concept Name |
Mirtazapine
|
| CHEBI_ID |
CHEBI:6950
|
| NCI_Drug_Dictionary_ID |
559298
|
| PDQ_Closed_Trial_Search_ID |
559298
|
| Preferred_Name |
Mirtazapine
|
| Display_Name |
Mirtazapine
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C29265
|
| DEFINITION |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.
|
| UMLS_CUI |
C0049506
|
| code |
C29265
|
| Chemical_Formula |
C17H19N3
|
| subClassOf | |
| type | |
| CAS_Registry |
61337-67-5
85650-52-8
|
| FULL_SYN |
MIRTAZAPINE
mirtazapine
Mirtazapine
Remeron
|
| FDA_UNII_Code |
A051Q2099Q
|
| ALT_DEFINITION |
A drug used to treat depression. It belongs to the family of drugs called antidepressant agents.
|
| PDQ_Open_Trial_Search_ID |
559298
|
| Contributing_Source |
CTRP
FDA
|
| Concept_In_Subset |
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