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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29150
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29150
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|---|---|
| Preferred Name | Lansoprazole |
| Definitions |
A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
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| Synonyms |
Lansoprazole
LANSOPRAZOLE
Prevacid
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Lansoprazole
|
|---|---|
| Legacy Concept Name |
Lansoprazole
|
| CHEBI_ID |
CHEBI:6375
|
| NCI_Drug_Dictionary_ID |
483101
|
| PDQ_Closed_Trial_Search_ID |
483101
|
| Preferred_Name |
Lansoprazole
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C29150
|
| DEFINITION |
A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
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| UMLS_CUI |
C0050940
|
| code |
C29150
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| Chemical_Formula |
C16H14F3N3O2S
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| subClassOf | |
| type | |
| CAS_Registry |
103577-45-3
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| FULL_SYN |
Lansoprazole
LANSOPRAZOLE
Prevacid
|
| FDA_UNII_Code |
0K5C5T2QPG
|
| PDQ_Open_Trial_Search_ID |
483101
|
| Contributing_Source |
FDA
HemOnc
|
| Concept_In_Subset |
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