National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29148
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29148
Preferred Name

Lactulose
Definitions
A disaccharide (sugar) synthesized from fructose and galactose, Lactulose is used to treat constipation and some liver diseases. Nondigestible in mammals, lactulose passes unabsorbed down to the large intestine where resident bacteria consume it and produce lactic, acetic, and formic acids, which draw fluid into the bowel to soften the stool (laxative effect). Acidification of the colon contents attracts ammonia from the bloodstream, assisting stool excretion; helpful in liver failure when ammonia cannot be detoxified. (NCI04)
Synonyms
4-O-beta-D-Galactopyranosyl-D-fructofuranose
Cephulac
Chronulac
LACTULOSE
Lactulose
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Lactulose
Legacy Concept Name
Lactulose
CHEBI_ID
CHEBI:6359
Preferred_Name
Lactulose
Semantic_Type
Organic Chemical
Pharmacologic Substance
prefixIRI
Thesaurus:C29148
DEFINITION
A disaccharide (sugar) synthesized from fructose and galactose, Lactulose is used to treat constipation and some liver diseases. Nondigestible in mammals, lactulose passes unabsorbed down to the large intestine where resident bacteria consume it and produce lactic, acetic, and formic acids, which draw fluid into the bowel to soften the stool (laxative effect). Acidification of the colon contents attracts ammonia from the bloodstream, assisting stool excretion; helpful in liver failure when ammonia cannot be detoxified. (NCI04)
UMLS_CUI
C0022957
code
C29148
subClassOf
type
CAS_Registry
4618-18-2
FULL_SYN
4-O-beta-D-Galactopyranosyl-D-fructofuranose
Cephulac
Chronulac
LACTULOSE
Lactulose
FDA_UNII_Code
9U7D5QH5AE
Contributing_Source
FDA
HemOnc
Concept_In_Subset
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