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National Cancer Institute Thesaurus
Last uploaded:
June 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29076
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29076
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|---|---|
| Preferred Name | Glyburide |
| Definitions |
A sulfonamide urea derivative with antihyperglycemic activity that can potentially be used to decrease cerebral edema. Upon administration, glyburide binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward current flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. In addition, glyburide also inhibits the SUR1-regulated nonselective cation (NC) Ca-ATP channel, melastatin 4 (transient receptor potential cation channel subfamily M member 4; (TRPM4)), thereby preventing capillary failure and brain swelling. SUR1-TRPM4 channels are formed by co-assembly of SUR1 with TRPM4 in neurons, astrocytes, and capillary endothelium during cerebral ischemia. Upon ischemia-induced ATP depletion, channels open which results in sodium influx, cytotoxic edema formation, capillary fragmentation and necrotic cell death. SUR1-TRPM4 is not expressed in normal, uninjured tissues.
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| Synonyms |
Glibenclamide
Diabeta
GLYBURIDE
Glyburide
Micronase
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Glyburide
|
|---|---|
| prefixIRI | Thesaurus:C29076
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| code | C29076
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| DEFINITION | A sulfonamide urea derivative with antihyperglycemic activity that can potentially be used to decrease cerebral edema. Upon administration, glyburide binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward current flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. In addition, glyburide also inhibits the SUR1-regulated nonselective cation (NC) Ca-ATP channel, melastatin 4 (transient receptor potential cation channel subfamily M member 4; (TRPM4)), thereby preventing capillary failure and brain swelling. SUR1-TRPM4 channels are formed by co-assembly of SUR1 with TRPM4 in neurons, astrocytes, and capillary endothelium during cerebral ischemia. Upon ischemia-induced ATP depletion, channels open which results in sodium influx, cytotoxic edema formation, capillary fragmentation and necrotic cell death. SUR1-TRPM4 is not expressed in normal, uninjured tissues.
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| CHEBI_ID | CHEBI:5441
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| Legacy Concept Name | Glyburide
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| PDQ_Open_Trial_Search_ID | 772960
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| Contributing_Source |
CTRP
FDA
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| NCI_Drug_Dictionary_ID | 772960
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| FULL_SYN |
Glibenclamide
Diabeta
GLYBURIDE
Glyburide
Micronase
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| Chemical_Formula | C23H28ClN3O5S
|
| UMLS_CUI | C0017628
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| FDA_UNII_Code | SX6K58TVWC
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| Preferred_Name | Glyburide
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| type | |
| subClassOf | |
| Display_Name | Glyburide
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| PDQ_Closed_Trial_Search_ID | 772960
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| CAS_Registry | 10238-21-8
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| Concept_In_Subset | |
| Semantic_Type | Pharmacologic Substance
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