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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29027
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29027
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|---|---|
| Preferred Name | Efavirenz |
| Definitions |
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.
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| Synonyms |
DMP-266
EFAVIRENZ
Efavirenz
L743726
MK-0831
Sustiva
efavirenz
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Efavirenz
|
|---|---|
| Legacy Concept Name |
Efavirenz
|
| CHEBI_ID |
CHEBI:119486
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| NCI_Drug_Dictionary_ID |
540650
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| PDQ_Closed_Trial_Search_ID |
540650
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| Preferred_Name |
Efavirenz
|
| Display_Name |
Efavirenz
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C29027
|
| DEFINITION |
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.
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| UMLS_CUI |
C0674428
|
| code |
C29027
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| Chemical_Formula |
C14H9ClF3NO2
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| subClassOf | |
| type | |
| CAS_Registry |
154598-52-4
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| FULL_SYN |
DMP-266
EFAVIRENZ
Efavirenz
L743726
MK-0831
Sustiva
efavirenz
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|
| FDA_UNII_Code |
JE6H2O27P8
|
| ALT_DEFINITION |
A drug used with other drugs to treat infection with the human immunodeficiency virus (HIV). It blocks HIV from making copies of itself. It is a type of non-nucleoside reverse transcriptase inhibitor and a type of antiviral agent.
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| PDQ_Open_Trial_Search_ID |
540650
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| Contributing_Source |
CTRP
FDA
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| Concept_In_Subset |
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