loading...| Preferred Name | Lamivudine/Zidovudine | |
| Synonyms |
Lamivudine/Zidovudine Combivir |
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| Definitions |
A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28939 |
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| code |
C28939 |
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| Concept_Status |
Obsolete_Concept |
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| DEFINITION |
A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04) |
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| FULL_SYN |
Lamivudine/Zidovudine Combivir |
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| label |
Lamivudine/Zidovudine |
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| Legacy Concept Name |
Lamivudine_Zidovudine |
|
| Preferred_Name |
Lamivudine/Zidovudine |
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| prefixIRI |
Thesaurus:C28939 |
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| Semantic_Type |
Therapeutic or Preventive Procedure |
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| UMLS_CUI |
C0717880 |
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| subClassOf |