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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28922
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28922
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|---|---|
| Preferred Name | Chloral Hydrate |
| Definitions |
A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system.
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| Synonyms |
CHLORAL HYDRATE
Chloral Hydrate
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Chloral Hydrate
|
|---|---|
| Legacy Concept Name |
Chloral_Hydrate
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| CHEBI_ID |
CHEBI:28142
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| Preferred_Name |
Chloral Hydrate
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C28922
|
| DEFINITION |
A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system.
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| UMLS_CUI |
C0008161
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| code |
C28922
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| Chemical_Formula |
C2H3Cl3O2
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| subClassOf | |
| type | |
| CAS_Registry |
302-17-0
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| FULL_SYN |
CHLORAL HYDRATE
Chloral Hydrate
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| FDA_UNII_Code |
418M5916WG
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| Contributing_Source |
FDA
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| Concept_In_Subset |
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