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National Cancer Institute Thesaurus
| Preferred Name | Azaserine | |
| Synonyms |
Diazoacetylserine Serine Diazoacetate L-Diazoacetate(ester) serine Diazoacetate (Ester) L-Serine Diazoacetic Acid Ester with Serine L-serine diazoacetate (ester) L-Azaserine o-Diazoacetyl-L-serine L-diazoacetate (ester) serine O-diazoacetyl-L-serine Diazoacetate(ester) L-serine AZASERINE AZS Azaserine CL-337 CN 15757 CN-15757 Cl 337 P-165 |
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| Definitions |
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C289 |
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| CAS_Registry |
115-02-6
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|
| Chemical_Formula |
C5H7N3O4
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|
| code |
C289
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC
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|
| DEFINITION |
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. (NCI04)
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|
| FDA_UNII_Code |
87299V3Q9W
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|
| FULL_SYN |
Diazoacetylserine Serine Diazoacetate L-Diazoacetate(ester) serine Diazoacetate (Ester) L-Serine Diazoacetic Acid Ester with Serine L-serine diazoacetate (ester) L-Azaserine o-Diazoacetyl-L-serine L-diazoacetate (ester) serine O-diazoacetyl-L-serine Diazoacetate(ester) L-serine AZASERINE AZS Azaserine CL-337 CN 15757 CN-15757 Cl 337 P-165
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| Is_Value_For_GDC_Property | ||
| label |
Azaserine
|
|
| Legacy Concept Name |
Azaserine
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|
| Maps_To |
Azaserine
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|
| NCI_Drug_Dictionary_ID |
39156
|
|
| NSC Number |
742
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|
| PDQ_Closed_Trial_Search_ID |
39156
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|
| PDQ_Open_Trial_Search_ID |
39156
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|
| Preferred_Name |
Azaserine
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|
| prefixIRI |
Thesaurus:C289
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|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide Antibiotic
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|
| UMLS_CUI |
C0004480
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| subClassOf |
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