loading...| Preferred Name |
High Affinity Nerve Growth Factor Receptor |
|
| Synonyms |
Tyrosine Kinase Receptor A Tyrosine Kinase Receptor Nerve Growth Factor Receptor Type 1 Tropomyosin-Related Kinase A TRK1-Transforming Tyrosine Kinase Protein EC 2.7.10.1 High Affinity Nerve Growth Factor Receptor Neurotrophic Tyrosine Kinase Receptor Type 1 NTRK1 Trk-A TrkA gp140trk p140-TrkA |
|
| Definitions |
High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and receptor-mediated signaling. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28558 |
|
| code |
C28558 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and receptor-mediated signaling. |
|
| DesignNote |
NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate development and function of the nociceptive and thermoregulatory nervous systems. Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1, and ERK1 signaling pathways. |
|
| Display_Name |
High Affinity Nerve Growth Factor Receptor |
|
| FULL_SYN |
Tyrosine Kinase Receptor A Tyrosine Kinase Receptor Nerve Growth Factor Receptor Type 1 Tropomyosin-Related Kinase A TRK1-Transforming Tyrosine Kinase Protein EC 2.7.10.1 High Affinity Nerve Growth Factor Receptor Neurotrophic Tyrosine Kinase Receptor Type 1 NTRK1 Trk-A TrkA gp140trk p140-TrkA |
|
| label |
High Affinity Nerve Growth Factor Receptor |
|
| Legacy Concept Name |
Neurotrophic_Tyrosine_Kinase_Receptor_Type-1 |
|
| NCI_META_CUI |
CL1648602 |
|
| OMIM_Number |
191315 |
|
| Preferred_Name |
High Affinity Nerve Growth Factor Receptor |
|
| prefixIRI |
Thesaurus:C28558 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme Receptor |
|
| Swiss_Prot |
P04629 |
|
| subClassOf |