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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2827
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2827
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Preferred Name | Verapamil Hydrochloride |
Definitions |
The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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Synonyms |
(+-)-Verapamil hydrochloride
VERAPAMIL HYDROCHLORIDE
Verapamil hydrochloride
Verapamil Hydrochloride
Calan
Isoptin SR
Verelan
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
label | Verapamil Hydrochloride
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Legacy Concept Name | Verapamil_Hydrochloride
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CHEBI_ID | CHEBI:53188
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Preferred_Name | Verapamil Hydrochloride
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Display_Name | Verapamil Hydrochloride
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Semantic_Type |
Organic Chemical
Pharmacologic Substance
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prefixIRI | Thesaurus:C2827
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DEFINITION | The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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UMLS_CUI | C0700468
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code | C2827
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Chemical_Formula | C27H38N2O4.ClH
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subClassOf | |
NSC Number |
272366
657799
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type | |
CAS_Registry | 152-11-4
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FULL_SYN |
(+-)-Verapamil hydrochloride
VERAPAMIL HYDROCHLORIDE
Verapamil hydrochloride
Verapamil Hydrochloride
Calan
Isoptin SR
Verelan
See more
See less
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FDA_UNII_Code | V3888OEY5R
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Contributing_Source |
CTRP
FDA
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Concept_In_Subset | |
Has_Free_Acid_Or_Base_Form |
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/ontologies/NCIT/notes/https%3A%2F%2Fdata.bioontology.org%2Fnotes%2F8dfd5db0-bd90-0136-3c5b-005056010073 | tabasco_tabata%40yahoo.co.jp | Comment | 2018-10-29 | |
New concept - total skin sparing mastectomy | anonymous | Comment | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15277 | 2013-05-22 |
RE: Antineoplastic antibiotics are antibiotics (?) | rwynne | Comment | 2013-02-13 | |
Antineoplastic antibiotics are antibiotics (?) | coulet | Comment | 2013-01-25 | |
Test note | decorons | Comment | 2011-02-07 | |
New Term Proposal: abcd | fergerson | New Class Proposal | 2010-12-17 | |
relationship with Smoking Behavior | pkcourtney | Comment | 2010-06-22 | |
causes and symptoms | linairis | Comment | 2009-08-06 | |
NIH-What Causes COPD | linairis | Comment | 2009-08-06 | |
The treatment of COPD | linairis | Comment | 2009-08-06 | |
MedlinePlus | linairis | Comment | 2009-08-06 | |
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
An image example for melanoma | jonquet | Comment | 2008-08-06 | |
Wikipedia page on 'melanoma' | jonquet | Comment | 2008-08-06 |
Showing 1 to 17 of 17 entries
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Example 1 (start typing the class name to get its full URI)
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