National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2827
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2827
Preferred Name

Verapamil Hydrochloride

Definitions
The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Synonyms
(+-)-Verapamil hydrochloride
VERAPAMIL HYDROCHLORIDE
Verapamil hydrochloride
Verapamil Hydrochloride
Calan
Isoptin SR
Verelan
Type http://www.w3.org/2002/07/owl#Class
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