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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Verapamil Hydrochloride | |
| Synonyms |
(+-)-Verapamil hydrochloride VERAPAMIL HYDROCHLORIDE Verapamil hydrochloride Verapamil Hydrochloride Calan Isoptin SR Verelan |
|
| Definitions |
The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2827 |
|
| CAS_Registry |
152-11-4
|
|
| CHEBI_ID |
CHEBI:53188
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|
| Chemical_Formula |
C27H38N2O4.ClH
|
|
| code |
C2827
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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|
| Display_Name |
Verapamil Hydrochloride
|
|
| FDA_UNII_Code |
V3888OEY5R
|
|
| FULL_SYN |
(+-)-Verapamil hydrochloride VERAPAMIL HYDROCHLORIDE Verapamil hydrochloride Verapamil Hydrochloride Calan Isoptin SR Verelan
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Verapamil Hydrochloride
|
|
| Legacy Concept Name |
Verapamil_Hydrochloride
|
|
| NSC Number |
272366 657799
|
|
| Preferred_Name |
Verapamil Hydrochloride
|
|
| prefixIRI |
Thesaurus:C2827
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0700468
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|
| subClassOf |
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