National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Bromelains
Synonyms

Pineapple Protease

EC 3.4.22.33

Ananase

BROMELAINS

Bromelain

Bromelains

Bromelase

Extranase

bromelain

Definitions

A proteolytic enzyme obtained from the pineapple plant that cleaves sulfhydryl groups. The enzyme is adsorbed intact through the gastrointestinal tract and has demonstrated therapeutic benefit. Bromelain has the ability to modulate cytokines, and has also demonstrated anti-inflammatory activity, immune response activity, and fibrinolytic activity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28134

ALT_DEFINITION

An enzyme found in pineapples that breaks down other proteins, such as collagen and muscle fiber, and has anti-inflammatory properties. It is used as a meat tenderizer in the food industry.

CAS_Registry

9001-00-7

code

C28134

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A proteolytic enzyme obtained from the pineapple plant that cleaves sulfhydryl groups. The enzyme is adsorbed intact through the gastrointestinal tract and has demonstrated therapeutic benefit. Bromelain has the ability to modulate cytokines, and has also demonstrated anti-inflammatory activity, immune response activity, and fibrinolytic activity.

FDA_UNII_Code

U182GP2CF3

FULL_SYN

Pineapple Protease

EC 3.4.22.33

Ananase

BROMELAINS

Bromelain

Bromelains

Bromelase

Extranase

bromelain

label

Bromelains

Legacy Concept Name

Bromelain

NCI_Drug_Dictionary_ID

459959

NSC Number

163804

PDQ_Closed_Trial_Search_ID

459959

PDQ_Open_Trial_Search_ID

459959

Preferred_Name

Bromelains

prefixIRI

Thesaurus:C28134

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

Enzyme

UMLS_CUI

C0006217

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C308

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