National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ziv-Aflibercept

Synonyms

VEGF Trap R1R2

Vascular Endothelial Growth Factor Trap

Ziv-aflibercept

aflibercept

Aflibercept

vascular endothelial growth factor trap

AFLIBERCEPT

Ziv-Aflibercept

AVE0005

Eylea

VEGF Trap

VEGF-Trap

Zaltrap

Definitions

A recombinant protein comprised of epitopes of the extracellular domains of human vascular endothelial growth factor receptors (VEGFR) fused to the constant region (Fc) of human IgG1 with potential antiangiogenic activity. Afilbercept, functioning as a soluble decoy receptor, binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to their endogenous receptors. Disruption of the binding of VEGFs to their cellular receptors may result in the inhibition of tumor angiogenesis, metastasis, and ultimately tumor regression.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2682

ALT_DEFINITION

A substance being studied in the treatment of several types of cancer. Vascular endothelial growth factor trap blocks the action of vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

CAS_Registry

862111-32-8

code

C2682

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

A recombinant protein comprised of epitopes of the extracellular domains of human vascular endothelial growth factor receptors (VEGFR) fused to the constant region (Fc) of human IgG1 with potential antiangiogenic activity. Afilbercept, functioning as a soluble decoy receptor, binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to their endogenous receptors. Disruption of the binding of VEGFs to their cellular receptors may result in the inhibition of tumor angiogenesis, metastasis, and ultimately tumor regression.

Display_Name

Ziv-Aflibercept

FDA_UNII_Code

15C2VL427D

FULL_SYN

VEGF Trap R1R2

Vascular Endothelial Growth Factor Trap

Ziv-aflibercept

aflibercept

Aflibercept

vascular endothelial growth factor trap

AFLIBERCEPT

Ziv-Aflibercept

AVE0005

Eylea

VEGF Trap

VEGF-Trap

Zaltrap

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17293

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Ziv-Aflibercept

Legacy Concept Name

VEGF_Trap

Maps_To

Ziv-Aflibercept

NCI_Drug_Dictionary_ID

38652

NSC Number

724770

PDQ_Closed_Trial_Search_ID

38652

PDQ_Open_Trial_Search_ID

38652

Preferred_Name

Ziv-Aflibercept

prefixIRI

Thesaurus:C2682

Semantic_Type

Pharmacologic Substance

Immunologic Factor

UMLS_CUI

C1134659

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C198860

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1971

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