National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2678
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2678
Preferred Name

Beta-Glucan
Definitions
A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04)
Synonyms
beta-glucan
Beta-Glucan
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Beta-Glucan
Maps_To
Beta-Glucan
Legacy Concept Name
Beta-Glucan
CHEBI_ID
CHEBI:28793
NCI_Drug_Dictionary_ID
38642
Is_Value_For_GDC_Property
PDQ_Closed_Trial_Search_ID
38642
Preferred_Name
Beta-Glucan
Display_Name
Beta-Glucan
Semantic_Type
Organic Chemical
Pharmacologic Substance
prefixIRI
Thesaurus:C2678
DEFINITION
A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04)
UMLS_CUI
C1134651
code
C2678
subClassOf
type
FULL_SYN
beta-glucan
Beta-Glucan
ALT_DEFINITION
A substance found in bacteria, plants, and certain foods, such as baker's yeast, cereal grains, and mushrooms. It is a type of polysaccharide that is made of a string of glucose (sugar) molecules joined together. Beta-glucan may stimulate the immune system and help kill cancer cells. It is being studied in the treatment of cancer. It is a type of biological response modifier.
PDQ_Open_Trial_Search_ID
38642
Contributing_Source
CTRP
GDC
Concept_In_Subset
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