loading...| Preferred Name |
Hexaminolevulinate |
|
| Synonyms |
Hexaminolevulinate hexyl 5-aminolevulinate Hexyl 5-Aminolevulinate HEXAMINOLEVULINATE HAL HexvixR |
|
| Definitions |
The hexyl ester of 5-aminolevulinic acid (ALA) with photodynamic properties. As a precursor of photoactive porphorins, hexyl 5-aminolevulinate induces the endogenous production of the photosensitizer protoporphyrin IX (PPIX) which accumulates selectively in tumor tissue. When exposed to specific wavelengths of light, PPIX is activated and, depending on the wavelength and/or intensity of light, either fluoresces, thereby allowing tumor imaging, or induces tumor cell apoptosis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26654 |
|
| ALT_DEFINITION |
A substance that is used to find and kill tumor cells. It enters tumor cells and becomes activated when exposed to a special type of light. A chemical reaction causes the cells to produce fluorescent light and die. |
|
| CAS_Registry |
140898-97-1 |
|
| Chemical_Formula |
C11H21NO3 |
|
| code |
C26654 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hexyl ester of 5-aminolevulinic acid (ALA) with photodynamic properties. As a precursor of photoactive porphorins, hexyl 5-aminolevulinate induces the endogenous production of the photosensitizer protoporphyrin IX (PPIX) which accumulates selectively in tumor tissue. When exposed to specific wavelengths of light, PPIX is activated and, depending on the wavelength and/or intensity of light, either fluoresces, thereby allowing tumor imaging, or induces tumor cell apoptosis. |
|
| Display_Name |
Hexaminolevulinate |
|
| FDA_UNII_Code |
G7H20TKI67 |
|
| FULL_SYN |
Hexaminolevulinate hexyl 5-aminolevulinate Hexyl 5-Aminolevulinate HEXAMINOLEVULINATE HAL HexvixR |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Hexaminolevulinate |
|
| Legacy Concept Name |
Hexyl_5-Aminolevulinate |
|
| Maps_To |
Hexaminolevulinate |
|
| NCI_Drug_Dictionary_ID |
269130 |
|
| PDQ_Closed_Trial_Search_ID |
269130 |
|
| PDQ_Open_Trial_Search_ID |
269130 |
|
| Preferred_Name |
Hexaminolevulinate |
|
| prefixIRI |
Thesaurus:C26654 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1327841 |
|
| subClassOf |