loading...| Preferred Name |
Interferon Regulatory Factor 3 |
|
| Synonyms |
Interferon Regulatory Factor 3 IRF-3 IRF3 |
|
| Definitions |
Interferon regulatory factor 3 (427 aa, ~47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral activity and interferon-stimulated response element promoter activation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26625 |
|
| code |
C26625 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
Interferon regulatory factor 3 (427 aa, ~47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral activity and interferon-stimulated response element promoter activation. |
|
| DesignNote |
IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (EntrezGene) |
|
| Display_Name |
Interferon Regulatory Factor 3 |
|
| FULL_SYN |
Interferon Regulatory Factor 3 IRF-3 IRF3 |
|
| label |
Interferon Regulatory Factor 3 |
|
| Legacy Concept Name |
Interferon_Regulatory_Factor-3 |
|
| OMIM_Number |
603734 |
|
| Preferred_Name |
Interferon Regulatory Factor 3 |
|
| prefixIRI |
Thesaurus:C26625 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| Swiss_Prot |
Q14653 |
|
| UMLS_CUI |
C0384768 |
|
| subClassOf |