National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Growth/Differentiation Factor 5
Synonyms

Lipopolysaccharide-Associated Protein 4

GDF5 Protein

Growth/Differentiation Factor 5

Cartilage-Derived Morphogenetic Protein 1

Growth Differentiation Factor 5

LPS-Associated Protein 4

Cartilage-Derived Morphogenetic Protein-1

Bone Morphogenetic Protein 14

BMP-14

CDMP-1

GDF-5

GDF5

LAP-4

Definitions

Growth/differentiation factor 5 (501 aa, ~55 kDa) is encoded by the human GDF5 gene. This protein is involved in skeletal development.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26322

code

C26322

DEFINITION

Growth/differentiation factor 5 (501 aa, ~55 kDa) is encoded by the human GDF5 gene. This protein is involved in skeletal development.

DesignNote

Growth/differentiation factor 5 is predominantly expressed in long bones during human embryonic development.

The active growth factor is released from the precursor following proteolytic cleavage at arginine at amino acid position 381 which is the final amino acid in a polybasic proteolytic processing site. (EntrezGene and UniProt)

FULL_SYN

Lipopolysaccharide-Associated Protein 4

GDF5 Protein

Growth/Differentiation Factor 5

Cartilage-Derived Morphogenetic Protein 1

Growth Differentiation Factor 5

LPS-Associated Protein 4

Cartilage-Derived Morphogenetic Protein-1

Bone Morphogenetic Protein 14

BMP-14

CDMP-1

GDF-5

GDF5

LAP-4

label

Growth/Differentiation Factor 5

Legacy Concept Name

Growth_Differentiation_Factor-5

OMIM_Number

601146

Preferred_Name

Growth/Differentiation Factor 5

prefixIRI

Thesaurus:C26322

Semantic_Type

Amino Acid, Peptide, or Protein

Biologically Active Substance

Swiss_Prot

P43026

UMLS_CUI

C2003595

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20455

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