National Cancer Institute Thesaurus - Retinoic Acid Binding - Classes | NCBO BioPortal

National Cancer Institute Thesaurus

Last uploaded: February 23, 2024

Id	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26052 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26052
Preferred Name	Retinoic Acid Binding
Definitions	Retinoic Acid Binding consists of a biophysical interaction between retinoic acid (ligand) and a biological molecule, such as specific steroid receptor-like transcriptional regulator proteins containing an N-terminal modulating domain, a DNA-binding domain, and a C-terminal ligand-binding domain. The ligand-activated receptor complexes selectively bind as homodimers or heterodimers (with other steroid family receptors) to DNA response elements in target gene promoters, enhance transcriptional activity with coactivators, and mediate tissue growth and differentiation in embryogenesis, organogenesis, limb development, bone growth, and maintenance of normal epithelia.
Synonyms	Retinoic Acid Binding
Type	http://www.w3.org/2002/07/owl#Class

label	Retinoic Acid Binding
Legacy Concept Name	Retinoic_Acid_Binding
Preferred_Name	Retinoic Acid Binding
Semantic_Type	Molecular Function
prefixIRI	Thesaurus:C26052
DEFINITION	Retinoic Acid Binding consists of a biophysical interaction between retinoic acid (ligand) and a biological molecule, such as specific steroid receptor-like transcriptional regulator proteins containing an N-terminal modulating domain, a DNA-binding domain, and a C-terminal ligand-binding domain. The ligand-activated receptor complexes selectively bind as homodimers or heterodimers (with other steroid family receptors) to DNA response elements in target gene promoters, enhance transcriptional activity with coactivators, and mediate tissue growth and differentiation in embryogenesis, organogenesis, limb development, bone growth, and maintenance of normal epithelia.
UMLS_CUI	C1514916
code	C26052
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20139
type	http://www.w3.org/2002/07/owl#Class
FULL_SYN	Retinoic Acid Binding

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Add NCBO Web Widgets to your site for NCIT

Widget type	Widget demonstration
Jump To Type a class name from NCIT and jump to it in BioPortal Get code	Step 2: Follow the Instructions Download the quick_jump.js file and put it on your server Copy the code below and paste it to your HTML page Note: If you would like to use Quick Jump across multiple ontologies: You can enter a comma-separated list of ontology ids: var BP_ontology_id = "NCIt,SNOMEDCT"; You can set the variable to 'all' to search all ontologies in BioPortal: var BP_ontology_id = "all"; To include definitions in the Jump To drop-down, add the following variable in Javascript: var BP_include_definitions = true; In the code that you just pasted, make sure to change the path to the quick_jump.js file to point to the location where you put the file (relative to your HTML file) For example, if you put the quick_jump.js file in the same directory as your HTML file, this is the code you would use: <div id="bp_quick_jump"></div> <script type="text/javascript"> var BP_ontology_id = "NCIT";</script> <script src="quick_jump.js" type="text/javascript" charset="utf-8"></script> For more help visit NCBO Widget Wiki
Form Autocomplete Fill your form fields with classes from NCIT Get code	Example 1 (start typing the class name to get its full URI) Example 2 (get the ID for a class) Example 3 (get the preferred name for a class) Step 2: Follow the Instructions Download the form_complete.js file and put it on your server. In the header for the page where you want the form field, include the form_complete.js file. On your form, for the fields where you want to use the class-selection widget, specify the field's class in the following format: `bp_form_complete-{ontology_id_list}-{value}` For example, `bp_form_complete-NCIT-uri` will use NCI Thesaurus (ontology id is NCIT) and will put the class URI in the field after the user selects the class from the pull-down list. Note: In addition to single ontology ids, you can use a list: `bp_form_complete-NCIT,NCBITAXON-uri` OR use 'all' to search across all BioPortal ontologies: `bp_form_complete-all-uri` The autocomplete widget accesses ontology content from the latest version of the ontology. You can use the following parameters to select which value will be placed into the user-visible input field: `uri` put the complete URI of the class (e.g., http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C183258 ) `shortid` put the short id of the class, as used in BioPortal (e.g., "Common_Neoplasm"); `name` put the preferred name of the class (e.g., "Common Neoplasm"); In addition to the input element you defined, there are four hidden form elements that are created and then set when a user selects a class from the list. For example, if you create a field with this code: <input type="text" name="a" class="bp_form_complete-all-uri" size="100"/> The 'name' attribute is used to create the four following fields (note how the 'a' from the name attribute is appended to the id attribute): <input type="hidden" id="a_bioportal_preferred_name"> <input type="hidden" id="a_bioportal_concept_id"> <input type="hidden" id="a_bioportal_ontology_id"> <input type="hidden" id="a_bioportal_full_id"> Additional parameters are documented on the NCBO Widget Wiki For more help visit NCBO Widget Wiki
Visualization Display a visualization for a given class in NCIT Get code	Step 2: Follow the Instructions Copy the code below and paste it to your HTML page <iframe frameborder="0" src="/widgets/visualization?ontology=NCIT&class=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C183258&apikey=YOUR_API_KEY"></iframe> For more help visit NCBO Widget Wiki
Tree Widget Display a class tree with a search field for NCIT Get code	Step 2: Follow the Instructions Copy the code below and paste it to your HTML page <link rel="stylesheet" type="text/css" href="/widgets/jquery.ncbo.tree.css"> <script src="/widgets/jquery.ncbo.tree-2.0.2.js"></script> <div id="widget_tree"></div> var widget_tree = $("#widget_tree").NCBOTree({ apikey: "YOUR_API_KEY", ontology: "NCIT" }); You can also view a detailed demonstration For more help visit NCBO Widget Wiki