National Cancer Institute Thesaurus

Last uploaded: February 23, 2024

Preferred Name	RAS Family Gene
Synonyms	ras gene family RAS Family Gene
Definitions	A family of genes that encode structurally similar small GTPases involved in a variety of signal transduction pathways. Mutation of genes in this family is associated with cancer.
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25784
ALT_DEFINITION	A family of genes that may cause cancer when they are mutated (changed). They make proteins that are involved in cell signaling pathways, cell growth, and apoptosis (cell death). Agents that block the actions of a mutated ras gene or its protein may stop the growth of cancer. Members of the ras gene family include Kras, Hras, and Nras.
code	C25784
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977
Contributing_Source	CTRP
DEFINITION	A family of genes that encode structurally similar small GTPases involved in a variety of signal transduction pathways. Mutation of genes in this family is associated with cancer.
Display_Name	RAS Family Gene
FULL_SYN	ras gene family RAS Family Gene
label	RAS Family Gene
Legacy Concept Name	RAS_Family_Gene
Preferred_Name	RAS Family Gene
prefixIRI	Thesaurus:C25784
Semantic_Type	Gene or Genome
UMLS_CUI	C1335597
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18437

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Delete	Mapping To	Ontology	Source
	http://purl.obolibrary.org/obo/NCIT_C25784	BERO	LOOM
	http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#RAS_Family_Gene	TCO	LOOM