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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Rasburicase | |
| Synonyms |
Rasburicase rasburicase Recombinant Urate Oxidase RASBURICASE Urate Oxidase recombinant urate oxidase Elitek SR 29142 SR-29142 |
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| Definitions |
A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2404 |
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| Accepted_Therapeutic_Use_For |
Chemotherapy-induced acute hyperuricemia, treatment and prophylaxis
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| ALT_DEFINITION |
A drug used to treat high blood levels of uric acid in patients with leukemia, lymphoma, and other types of cancer who are receiving certain types of cancer treatment. It is also being studied in the treatment of other medical conditions. Elitek is a type of recombinant enzyme and a type of urate-lowering drug.
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| CAS_Registry |
134774-45-1
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|
| code |
C2404
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04)
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| Display_Name |
Rasburicase
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|
| FDA_UNII_Code |
08GY9K1EUO
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|
| FULL_SYN |
Rasburicase rasburicase Recombinant Urate Oxidase RASBURICASE Urate Oxidase recombinant urate oxidase Elitek SR 29142 SR-29142
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|
| label |
Rasburicase
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|
| Legacy Concept Name |
Rasburicase
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| NCI_Drug_Dictionary_ID |
299001
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|
| NSC Number |
721631
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|
| PDQ_Closed_Trial_Search_ID |
299001
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| PDQ_Open_Trial_Search_ID |
299001
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|
| Preferred_Name |
Rasburicase
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|
| prefixIRI |
Thesaurus:C2404
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0937932
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| subClassOf |
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