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National Cancer Institute Thesaurus
| Preferred Name | Immunohistochemistry Staining Method | |
| Synonyms |
Immunohistochemistry Staining Method Immunohistochemistry (IHC) immunohistochemistry Immunohistochemistry Cell/Tissue, Immunohistochemistry IHC |
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| Definitions |
Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23020 |
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| ALT_DEFINITION |
Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen. A technique used to identify specific molecules in different kinds of tissue. The tissue is treated with antibodies that bind the specific molecule. These are made visible under a microscope by using a color reaction, a radioisotope, colloidal gold, or a fluorescent dye. Immunohistochemistry is used to help diagnose diseases, such as cancer, and to detect the presence of microorganisms. It is also used in basic research to understand how cells grow and differentiate (become more specialized).
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| code |
C23020
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118169 |
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| Contributing_Source |
CDISC CTRP GDC
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| DEFINITION |
Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
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| Display_Name |
Immunohistochemistry Staining Method
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| FULL_SYN |
Immunohistochemistry Staining Method Immunohistochemistry (IHC) immunohistochemistry Immunohistochemistry Cell/Tissue, Immunohistochemistry IHC
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| Is_Value_For_GDC_Property | ||
| label |
Immunohistochemistry Staining Method
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| Legacy Concept Name |
Immunohistochemistry_Staining_Method
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| Maps_To |
Immunohistochemistry (IHC) IHC
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| Preferred_Name |
Immunohistochemistry Staining Method
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| prefixIRI |
Thesaurus:C23020
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| Semantic_Type |
Laboratory Procedure
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| UMLS_CUI |
C0021044
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| subClassOf |
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