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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Amikacin Sulfate | |
| Synonyms |
Amikacin Sulfate AMIKACIN SULFATE Amikin |
|
| Definitions |
The sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C230 |
|
| CAS_Registry |
39831-55-5
|
|
| CHEBI_ID |
CHEBI:2638
|
|
| Chemical_Formula |
C22H43N5O13.2H2O4S
|
|
| code |
C230
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.
|
|
| FDA_UNII_Code |
N6M33094FD
|
|
| FULL_SYN |
Amikacin Sulfate AMIKACIN SULFATE Amikin
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Amikacin Sulfate
|
|
| Legacy Concept Name |
Amikacin
|
|
| NCI_Drug_Dictionary_ID |
39145
|
|
| NSC Number |
177001
|
|
| PDQ_Closed_Trial_Search_ID |
39145
|
|
| PDQ_Open_Trial_Search_ID |
39145
|
|
| Preferred_Name |
Amikacin Sulfate
|
|
| prefixIRI |
Thesaurus:C230
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0700949
|
|
| subClassOf |
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