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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Alfentanil Hydrochloride | |
| Synonyms |
ALFENTANIL HYDROCHLORIDE Alfentanil Hydrochloride Alfenta Rapifen |
|
| Definitions |
The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C220 |
|
| CAS_Registry |
70879-28-6
|
|
| Chemical_Formula |
C21H32N6O3.ClH.H2O
|
|
| code |
C220
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited.
|
|
| FDA_UNII_Code |
11S92G0TIW
|
|
| FULL_SYN |
ALFENTANIL HYDROCHLORIDE Alfentanil Hydrochloride Alfenta Rapifen
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Alfentanil Hydrochloride
|
|
| Legacy Concept Name |
Alfentanil_Hydrochloride
|
|
| NCI_Drug_Dictionary_ID |
42783
|
|
| PDQ_Closed_Trial_Search_ID |
42783
|
|
| PDQ_Open_Trial_Search_ID |
42783
|
|
| Preferred_Name |
Alfentanil Hydrochloride
|
|
| prefixIRI |
Thesaurus:C220
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0002025
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|
| subClassOf |
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