National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Phosphatidylinositide 3-Kinase Inhibitor
Synonyms

Phosphatidylinositide 3-Kinase Inhibitor

PI3-Kinase Inhibitors

Phosphatidylinositol 3-kinase Inhibitor

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Inhibitor

PI3K Inhibitor
Definitions

Any substance that inhibits phosphatidylinositol 3-kinase (phosphatidylinositide 3-kinase), an enzyme that catalyzes the phosphorylation of the 3 position hydroxyl group of the inositol ring of phosphatidylinositol and functions as an intracellular signal transducer in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. Inhibition of phosphatidylinositol 3-kinase produces antiproliferative and antiangiogenic effects.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2152
CHEBI_ID

CHEBI:50914
code

C2152
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977
Contributing_Source

CTRP
DEFINITION

Any substance that inhibits phosphatidylinositol 3-kinase (phosphatidylinositide 3-kinase), an enzyme that catalyzes the phosphorylation of the 3 position hydroxyl group of the inositol ring of phosphatidylinositol and functions as an intracellular signal transducer in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. Inhibition of phosphatidylinositol 3-kinase produces antiproliferative and antiangiogenic effects.
Display_Name

PI3K Inhibitor
FULL_SYN

Phosphatidylinositide 3-Kinase Inhibitor

PI3-Kinase Inhibitors

Phosphatidylinositol 3-kinase Inhibitor

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Inhibitor

PI3K Inhibitor
label

Phosphatidylinositide 3-Kinase Inhibitor
Legacy Concept Name

Phosphatidylinositide_3-Kinase_Inhibitor
Preferred_Name

Phosphatidylinositide 3-Kinase Inhibitor
prefixIRI

Thesaurus:C2152
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C1519050
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1742

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163758

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1404
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http://purl.obolibrary.org/obo/NCIT_C2152 BERO LOOM