National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Epidermal Growth Factor Superfamily Protein
Synonyms

EGF Repeat Superfamily

Epidermal Growth Factor Superfamily Protein

Epidermal Growth Factor Repeat Superfamily
Definitions

Many Epidermal Growth Factor Superfamily Proteins are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. The EGF superfamily is characterized by having at least 6 cysteines residues that form disulphide bonds stacked in a ladder-like arrangement, in the order 1-3, 2-4, 5-6, and which are essential for the stability of the EGF fold. Often arranged as tandem repeats in extracellular proteins, the function of the domains remains unclear, but are thought to perform a structural role.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20970
code

C20970
DEFINITION

Many Epidermal Growth Factor Superfamily Proteins are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. The EGF superfamily is characterized by having at least 6 cysteines residues that form disulphide bonds stacked in a ladder-like arrangement, in the order 1-3, 2-4, 5-6, and which are essential for the stability of the EGF fold. Often arranged as tandem repeats in extracellular proteins, the function of the domains remains unclear, but are thought to perform a structural role.
FULL_SYN

EGF Repeat Superfamily

Epidermal Growth Factor Superfamily Protein

Epidermal Growth Factor Repeat Superfamily
label

Epidermal Growth Factor Superfamily Protein
Legacy Concept Name

Epidermal_Growth_Factor_Superfamily_Protein
Preferred_Name

Epidermal Growth Factor Superfamily Protein
prefixIRI

Thesaurus:C20970
Semantic_Type

Amino Acid, Peptide, or Protein
UMLS_CUI

C1333412
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20424
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