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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2076
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2076
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|---|---|
| Preferred Name | Polyamine Synthesis Inhibitor |
| Definitions |
A compound that inhibits the synthesis of the naturally occurring polyamines, intracellular compounds that bind to DNA and play a critical role in cell division, differentiation and membrane function. These inhibitors affect the activity of enzymes like ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMD) that are involved in the biosynthesis of polyamines. A reduction in intracellular polyamine concentration may lead to a decreased cell growth.
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| Synonyms |
Polyamine Inhibitor
Polyamine Synthesis Inhibitor
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Polyamine Synthesis Inhibitor
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|---|---|
| Legacy Concept Name |
Polyamine_Inhibitory_Agent
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| Preferred_Name |
Polyamine Synthesis Inhibitor
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| Semantic_Type |
Chemical Viewed Functionally
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| prefixIRI |
Thesaurus:C2076
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| DEFINITION |
A compound that inhibits the synthesis of the naturally occurring polyamines, intracellular compounds that bind to DNA and play a critical role in cell division, differentiation and membrane function. These inhibitors affect the activity of enzymes like ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMD) that are involved in the biosynthesis of polyamines. A reduction in intracellular polyamine concentration may lead to a decreased cell growth.
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| UMLS_CUI |
C1514194
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| code |
C2076
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| subClassOf | |
| type | |
| FULL_SYN |
Polyamine Inhibitor
Polyamine Synthesis Inhibitor
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