National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Transcription Coregulator Gene

Synonyms

Transcription Coactivator/Corepressor Gene

Transcriptional Coregulator Gene

Transcription Coregulator Gene

Definitions

RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20710

code

C20710

DEFINITION

RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)

FULL_SYN

Transcription Coactivator/Corepressor Gene

Transcriptional Coregulator Gene

Transcription Coregulator Gene

label

Transcription Coregulator Gene

Legacy Concept Name

Transcription_Coregulator_Gene

Preferred_Name

Transcription Coregulator Gene

prefixIRI

Thesaurus:C20710

Semantic_Type

Gene or Genome

UMLS_CUI

C1336778

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54362

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http://purl.obolibrary.org/obo/NCIT_C20710 BERO LOOM