Preferred Name |
Nuclear Receptor Gene |
|
Synonyms |
Nuclear Receptor Gene |
|
Definitions |
Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20709 |
|
code |
C20709 |
|
DEFINITION |
Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI) |
|
FULL_SYN |
Nuclear Receptor Gene |
|
Gene_Encodes_Product |
Nuclear Receptor |
|
label |
Nuclear Receptor Gene |
|
Legacy Concept Name |
Nuclear_Receptor_Gene |
|
Preferred_Name |
Nuclear Receptor Gene |
|
prefixIRI |
Thesaurus:C20709 |
|
Semantic_Type |
Gene or Genome |
|
UMLS_CUI |
C1335077 |
|
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://doe-generated-ontology.com/OntoAD#C1335077 | ONTOAD | LOOM | |
http://purl.obolibrary.org/obo/NCIT_C20709 | BERO | LOOM | |
http://purl.obolibrary.org/obo/NCIT_C20709 | GSSO | LOOM | |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Nuclear_Receptor_Gene | SEPON | LOOM |