One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine.

C20512

CTRP

Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.

Interleukin-10 down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.

Interleukin-10

T-Cell Growth Inhibitory Factor

Interleukin-10

Cytokine Synthesis Inhibitory Factor

Interleukin 10

interleukin-10

CSIF

IL-10

IL10

TGIF

Interleukin-10

Interleukin-10

124092

Interleukin-10

Thesaurus:C20512

Amino Acid, Peptide, or Protein

Immunologic Factor

P22301

C1699802