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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C205
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C205
|
|---|---|
| Preferred Name | Acyclovir |
| Definitions |
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization.
|
| Synonyms |
9-[(2-Hydroxyethoxy)-methyl]guanine
Wellcome-248U
2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
9-[(2-Hydroxyethoxy)methyl]guanine
Acycloguanosine
ACV
ACYCLOVIR
Acicloftal
Aciclovir
Aclovir
Acyclovir
BW-248U
Cargosil
Virorax
Zovirax
acyclovir
See more
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Acyclovir
|
|---|---|
| Legacy Concept Name |
Acyclovir
|
| CHEBI_ID |
CHEBI:2453
|
| NCI_Drug_Dictionary_ID |
810655
|
| Preferred_Name |
Acyclovir
|
| Display_Name |
Acyclovir
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
|
| prefixIRI |
Thesaurus:C205
|
| DEFINITION |
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization.
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| NCI_META_CUI |
CL523878
|
| code |
C205
|
| Chemical_Formula |
C8H11N5O3
|
| subClassOf | |
| NSC Number |
335752
645011
|
| type | |
| CAS_Registry |
59277-89-3
|
| FULL_SYN |
9-[(2-Hydroxyethoxy)-methyl]guanine
Wellcome-248U
2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
9-[(2-Hydroxyethoxy)methyl]guanine
Acycloguanosine
ACV
ACYCLOVIR
Acicloftal
Aciclovir
Aclovir
Acyclovir
BW-248U
Cargosil
Virorax
Zovirax
acyclovir
See more
See less
|
| FDA_UNII_Code |
X4HES1O11F
|
| ALT_DEFINITION |
A substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals.
|
| Contributing_Source |
CTRP
FDA
HemOnc
|
| Concept_In_Subset | |
| Has_Salt_Form |
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