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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Transforming Growth Factor Beta-2 | |
| Synonyms |
Cartilage-Inducing Factor-B Transforming Growth Factor-Beta 2 Transforming Growth Factor Beta 2 Transforming Growth Factor Beta-2 Glioblastoma-Derived T-Cell Suppressor Factor BSC-1 Cell Growth Inhibitor G-TSF Polyergin TGF-Beta 2 TGF-Beta2 TGF-b2 TGF-beta-2 TGFB2 |
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| Definitions |
Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20458 |
|
| code |
C20458
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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|
| DEFINITION |
Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways.
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| DesignNote |
TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)
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|
| Display_Name |
Transforming Growth Factor Beta-2
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|
| FULL_SYN |
Cartilage-Inducing Factor-B Transforming Growth Factor-Beta 2 Transforming Growth Factor Beta 2 Transforming Growth Factor Beta-2 Glioblastoma-Derived T-Cell Suppressor Factor BSC-1 Cell Growth Inhibitor G-TSF Polyergin TGF-Beta 2 TGF-Beta2 TGF-b2 TGF-beta-2 TGFB2
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|
| label |
Transforming Growth Factor Beta-2
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|
| Legacy Concept Name |
Transforming_Growth_Factor_Beta-2
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| OMIM_Number |
190220
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|
| Preferred_Name |
Transforming Growth Factor Beta-2
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|
| prefixIRI |
Thesaurus:C20458
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P61812
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| UMLS_CUI |
C1699342
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| subClassOf |
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