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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Transforming Growth Factor Beta-1 | |
| Synonyms |
Transforming Growth Factor-Beta 1 Transforming Growth Factor Beta-1 TGF-Beta 1 TGF-Beta-1 TGF-Beta1 TGFB1 |
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| Definitions |
Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20457 |
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| code |
C20457
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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| DEFINITION |
Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways.
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| DesignNote |
Transforming growth factor beta-1 is cleaved into the following product: latency-associated peptide. (UniProt) TGFB is a multifunctional peptide cytokine that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. SMAD proteins mediate TGFB signaling. SNON appears to maintain the repressed state of TGFB target genes in the absence of ligand and participates in negative feedback regulation of TGFB signaling. (from OMIM 190180 and NCI)
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| Display_Name |
Transforming Growth Factor Beta-1
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| FULL_SYN |
Transforming Growth Factor-Beta 1 Transforming Growth Factor Beta-1 TGF-Beta 1 TGF-Beta-1 TGF-Beta1 TGFB1
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|
| label |
Transforming Growth Factor Beta-1
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|
| Legacy Concept Name |
Transforming_Growth_Factor_Beta-1
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| OMIM_Number |
190180
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| Preferred_Name |
Transforming Growth Factor Beta-1
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| prefixIRI |
Thesaurus:C20457
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P01137
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| UMLS_CUI |
C0080222
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| subClassOf |
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