loading...| Preferred Name | Transforming Growth Factor Alpha | |
| Synonyms |
EGF-Like TGF Transforming Growth Factor, Alpha Transforming Growth Factor-Alpha Transforming Growth Factor Alpha Epidermal Growth Factor Related Transforming Growth Factor ETGF TGF A TGF Type 1 TGF-Alpha TGFA |
|
| Definitions |
Transforming growth factor alpha (50 aa, ~6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20454 |
|
| code |
C20454 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
Transforming growth factor alpha (50 aa, ~6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation. |
|
| DesignNote |
The active form of the growth factor, transforming growth factor alpha, is produced when proteolytic cleavage removes 39 amino acids from the N-terminus and 71 amino acids from the C-terminus of protransforming growth factor alpha. The precursor is a transmembrane protein and the mature form is a secreted protein. (UniProt) In esophageal adenocarcinoma patients who received high-dose radiation and chemotherapy, tumors that either persistently expressed or had increased TGFA expression was associated with a worse prognosis. (Int J Radiat Oncol Biol Phys. 1995; 31:567-9.) |
|
| Display_Name |
Transforming Growth Factor Alpha |
|
| FULL_SYN |
EGF-Like TGF Transforming Growth Factor, Alpha Transforming Growth Factor-Alpha Transforming Growth Factor Alpha Epidermal Growth Factor Related Transforming Growth Factor ETGF TGF A TGF Type 1 TGF-Alpha TGFA |
|
| label |
Transforming Growth Factor Alpha |
|
| Legacy Concept Name |
Transforming_Growth_Factor_Alpha |
|
| OMIM_Number |
190170 |
|
| Preferred_Name |
Transforming Growth Factor Alpha |
|
| prefixIRI |
Thesaurus:C20454 |
|
| PubMedID_Primary_Reference |
7852121 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| Swiss_Prot |
P01135 |
|
| UMLS_CUI |
C3849193 |
|
| subClassOf |