National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Actinomycin Antineoplastic Antibiotic

Synonyms

Actinomycins

Actinomycin Antineoplastic Antibiotic

Definitions

A chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin antibiotics inhibit DNA replication and RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA and interfering with the function of topoisomerase II.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C204

code

C204

DEFINITION

A chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin antibiotics inhibit DNA replication and RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA and interfering with the function of topoisomerase II.

FULL_SYN

Actinomycins

Actinomycin Antineoplastic Antibiotic

label

Actinomycin Antineoplastic Antibiotic

Legacy Concept Name

Actinomycin_Antibiotic

Preferred_Name

Actinomycin Antineoplastic Antibiotic

prefixIRI

Thesaurus:C204

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0001259

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2115

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http://purl.obolibrary.org/obo/NCIT_C204 BERO LOOM