loading...| Preferred Name | High Mobility Group Protein B1 | |
| Synonyms |
High Mobility Group Protein B1 High-Mobility Group (Nonhistone Chromosomal) Protein 1 High Mobility Group Protein 1 High-Mobility Group Box 1 Chromosomal Protein, Nonhistone, HMG1 Nonhistone Chromosomal Protein HGM1 Sulfoglucuronyl Carbohydrate Binding Protein Amphoterin HMG 1 HMG-1 HMG1 HMG3 HMGB1 SBP-1 |
|
| Definitions |
High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin structure and DNA topology. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20328 |
|
| code |
C20328 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin structure and DNA topology. |
|
| DesignNote |
HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221) |
|
| Display_Name |
High Mobility Group Protein B1 |
|
| FULL_SYN |
High Mobility Group Protein B1 High-Mobility Group (Nonhistone Chromosomal) Protein 1 High Mobility Group Protein 1 High-Mobility Group Box 1 Chromosomal Protein, Nonhistone, HMG1 Nonhistone Chromosomal Protein HGM1 Sulfoglucuronyl Carbohydrate Binding Protein Amphoterin HMG 1 HMG-1 HMG1 HMG3 HMGB1 SBP-1 |
|
| label |
High Mobility Group Protein B1 |
|
| Legacy Concept Name |
HMGB1 |
|
| OMIM_Number |
163905 |
|
| Preferred_Name |
High Mobility Group Protein B1 |
|
| prefixIRI |
Thesaurus:C20328 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| Swiss_Prot |
P09429 |
|
| UMLS_CUI |
C3710671 |
|
| subClassOf |