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National Cancer Institute Thesaurus
Last uploaded:
June 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2021
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2021
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|---|---|
| Preferred Name | Thymidylate Synthase Inhibitor |
| Definitions |
Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation.
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| Synonyms |
thymidylate synthase inhibitor
Thymidylate Synthase Inhibitor
Thymidylate Synthetase Inhibitors
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Thymidylate Synthase Inhibitor
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|---|---|
| prefixIRI | Thesaurus:C2021
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| code | C2021
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| DEFINITION | Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation.
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| ALT_DEFINITION | A drug that blocks DNA synthesis and may prevent tumor cell growth. It is being studied as a treatment for cancer.
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| CHEBI_ID | CHEBI:63720
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| Legacy Concept Name | Thymidylate_Synthase_Inhibitor
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| FULL_SYN |
thymidylate synthase inhibitor
Thymidylate Synthase Inhibitor
Thymidylate Synthetase Inhibitors
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| UMLS_CUI | C1373008
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| Preferred_Name | Thymidylate Synthase Inhibitor
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| type | |
| subClassOf | |
| Semantic_Type | Chemical Viewed Functionally
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