National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

IgG2
Synonyms

Immunoglobulin G2

Immunoglobulin G Subclass 2

IgG2
Definitions

The second most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG2 core hinge sequence contains 12 amino acids and up to four interchain disulfide bonds. This subtype has low affinity for binding both Fc receptors and complement component C1q. The production of this IgG2 is stimulated by exposure to bacterial capsular polysaccharides and other antigenic glycans.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201278
code

C201278
DEFINITION

The second most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG2 core hinge sequence contains 12 amino acids and up to four interchain disulfide bonds. This subtype has low affinity for binding both Fc receptors and complement component C1q. The production of this IgG2 is stimulated by exposure to bacterial capsular polysaccharides and other antigenic glycans.
FULL_SYN

Immunoglobulin G2

Immunoglobulin G Subclass 2

IgG2
label

IgG2
Preferred_Name

IgG2
prefixIRI

Thesaurus:C201278
PubMedID_Primary_Reference

25368619
Semantic_Type

Amino Acid, Peptide, or Protein

Immunologic Factor
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C568
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