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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C195
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C195
|
|---|---|
| Preferred Name | Mercaptopurine |
| Definitions |
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
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| Synonyms |
Purine, 6-mercapto-
Puri-Nethol
MERCAPTOPURINE
Purine-6-thiol (8CI)
Mercaptopurine
6-Mercaptopurine
6 Thiohypoxanthine
Purine-6-thiol, Monohydrate
6H-Purine-6-thione, 1,7-dihydro- (9CI)
Mercaptopurinum
Purine-6-thiol Monohydrate
6-Purinethiol
Alti-Mercaptopurine
1,7-Dihydro-6H-purine-6-thione
Mercapto-6-purine
6-Thiopurine
1,7-Dihydro-6H-purine-6-thione Monohydrate
6 Thiopurine
Purine-6-thiol, monohydrate
mercaptopurine
Purinethiol
7-Mercapto-1,3,4,6-tetrazaindene
6-Thioxopurine
3H-Purine-6-thiol
6-Mercaptopurine Monohydrate
Mercaleukin
Mercaleukim
Azathiopurine
6 MP
6-MP
BW 57-323H
Bw 57-323H
Flocofil
Ismipur
Leukerin
Leupurin
Mercaptina
Mercapurin
Mern
NCI-C04886
Purimethol
Purinethol
U-4748
WR-2785
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Mercaptopurine
|
|---|---|
| Maps_To |
Mercaptopurine
|
| Accepted_Therapeutic_Use_For |
Acute lymphocytic leukemia; Acute myelogenous leukemia; Crohns disease; Hodgkins lymphoma in children; Lymphoblastic lymphoma; Ulcerative colitis
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| Legacy Concept Name |
Mercaptopurine
|
| CHEBI_ID |
CHEBI:31822
|
| NCI_Drug_Dictionary_ID |
43436
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
43436
|
| Preferred_Name |
Mercaptopurine
|
| Display_Name |
Mercaptopurine
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| prefixIRI |
Thesaurus:C195
|
| DEFINITION |
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
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| UMLS_CUI |
C0000618
|
| code |
C195
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| Chemical_Formula |
C5H4N4S.H2O
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| subClassOf | |
| NSC Number |
755
|
| type | |
| CAS_Registry |
6112-76-1
|
| FULL_SYN |
Purine, 6-mercapto-
Puri-Nethol
MERCAPTOPURINE
Purine-6-thiol (8CI)
Mercaptopurine
6-Mercaptopurine
6 Thiohypoxanthine
Purine-6-thiol, Monohydrate
6H-Purine-6-thione, 1,7-dihydro- (9CI)
Mercaptopurinum
Purine-6-thiol Monohydrate
6-Purinethiol
Alti-Mercaptopurine
1,7-Dihydro-6H-purine-6-thione
Mercapto-6-purine
6-Thiopurine
1,7-Dihydro-6H-purine-6-thione Monohydrate
6 Thiopurine
Purine-6-thiol, monohydrate
mercaptopurine
Purinethiol
7-Mercapto-1,3,4,6-tetrazaindene
6-Thioxopurine
3H-Purine-6-thiol
6-Mercaptopurine Monohydrate
Mercaleukin
Mercaleukim
Azathiopurine
6 MP
6-MP
BW 57-323H
Bw 57-323H
Flocofil
Ismipur
Leukerin
Leupurin
Mercaptina
Mercapurin
Mern
NCI-C04886
Purimethol
Purinethol
U-4748
WR-2785
See more
See less
|
| FDA_UNII_Code |
E7WED276I5
|
| ALT_DEFINITION |
A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites.
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| PDQ_Open_Trial_Search_ID |
43436
|
| Contributing_Source |
CTRP
FDA
GDC
HemOnc
|
| Concept_In_Subset |
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