National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
loading...
Preferred Name

Recombinant Tumor Necrosis Factor Family Protein
Synonyms

tumor necrosis factor

Tumor Necrosis Factors

Recombinant Tumor Necrosis Factor Family Protein

Tumor Necrosis Factor Family Protein

TNF
Definitions

A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF) proteins. TNF family cytokines bind to and activate specific cell-surface receptors, thereby mediating inflammatory processes, cell proliferation, immunity, angiogenesis, and tumor cell cytotoxicity. One primary antitumor effect of TNFs involves stimulation of T cell-mediated antitumor cytotoxicity.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1941
ALT_DEFINITION

A protein made by white blood cells in response to an antigen (substance that causes the immune system to make a specific immune response) or infection. Tumor necrosis factor can also be made in the laboratory. It may boost a person's immune response, and also may cause necrosis (cell death) of some types of tumor cells. Tumor necrosis factor is being studied in the treatment of some types of cancer. It is a type of cytokine.
code

C1941
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784
Contributing_Source

CTRP
DEFINITION

A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF) proteins. TNF family cytokines bind to and activate specific cell-surface receptors, thereby mediating inflammatory processes, cell proliferation, immunity, angiogenesis, and tumor cell cytotoxicity. One primary antitumor effect of TNFs involves stimulation of T cell-mediated antitumor cytotoxicity.
Display_Name

Recombinant Tumor Necrosis Factor Family Protein
FULL_SYN

tumor necrosis factor

Tumor Necrosis Factors

Recombinant Tumor Necrosis Factor Family Protein

Tumor Necrosis Factor Family Protein

TNF
label

Recombinant Tumor Necrosis Factor Family Protein
Legacy Concept Name

Therapeutic_Tumor_Necrosis_Factor_Family_Protein
NCI_Drug_Dictionary_ID

40250
NSC Number

349993

604175
PDQ_Closed_Trial_Search_ID

40250
PDQ_Open_Trial_Search_ID

40250
Preferred_Name

Recombinant Tumor Necrosis Factor Family Protein
prefixIRI

Thesaurus:C1941
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C1522668
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1283
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display