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National Cancer Institute Thesaurus
Last uploaded:
July 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18434
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18434
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|---|---|
| Preferred Name | Topoisomerase II |
| Definitions |
Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI)
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| Synonyms |
Topoisomerase 2
DNA Topoisomerase II
Topoisomerase II
TOP2
Topo II
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Topoisomerase II
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|---|---|
| prefixIRI | Thesaurus:C18434
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| code | C18434
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| DEFINITION | Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI)
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| Legacy Concept Name | Topoisomerase-II
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| Contributing_Source | CTRP
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| FULL_SYN |
Topoisomerase 2
DNA Topoisomerase II
Topoisomerase II
TOP2
Topo II
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| UMLS_CUI | C0012863
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| Preferred_Name | Topoisomerase II
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| type | |
| subClassOf | |
| Display_Name | Topoisomerase II
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| Concept_In_Subset | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| DesignNote | DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA.
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| Delete | Subject | Author | Type | Created |
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