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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1818
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1818
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|---|---|
| Preferred Name | Ursodiol |
| Definitions |
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract.
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| Synonyms |
Ursodeoxycholic acid
Ursodeoxycholic Acid
(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid
Actigall
Deursil
UDCA
URSO
URSODIOL
Ursodiol
ursodiol
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Ursodiol
|
|---|---|
| Accepted_Therapeutic_Use_For |
Gallstone disolution; Primary biliary cirrhosis
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| Legacy Concept Name |
Ursodiol
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| CHEBI_ID |
CHEBI:9907
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| NCI_Drug_Dictionary_ID |
306453
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| PDQ_Closed_Trial_Search_ID |
306453
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| Preferred_Name |
Ursodiol
|
| Display_Name |
Ursodiol
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C1818
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| DEFINITION |
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract.
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| UMLS_CUI |
C0042105
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| code |
C1818
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| Chemical_Formula |
C24H40O4
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| subClassOf | |
| NSC Number |
657950
683769
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| type | |
| CAS_Registry |
128-13-2
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| FULL_SYN |
Ursodeoxycholic acid
Ursodeoxycholic Acid
(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid
Actigall
Deursil
UDCA
URSO
URSODIOL
Ursodiol
ursodiol
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|
| FDA_UNII_Code |
724L30Y2QR
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| ALT_DEFINITION |
A drug that is used to dissolve gallstones in people who can't have surgery to remove them. It is also being studied in the prevention of colorectal cancer. Ursodiol belongs to the family of drugs called anticholelithics.
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| PDQ_Open_Trial_Search_ID |
306453
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| Contributing_Source |
CTRP
FDA
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| Concept_In_Subset |
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