National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Baculoviral IAP Repeat-Containing Protein 5
Synonyms

Apoptosis Inhibitor Survivin

Baculoviral IAP Repeat-Containing 5 (Survivin)

Baculoviral IAP Repeat-Containing Protein 5

Apoptosis Inhibitor 4

API4

BIRC5

EPR-1

IAP4

Survivin

Definitions

Baculoviral IAP repeat-containing protein 5 (142 aa, ~16 kDa) is encoded by the human BIRC5 gene. This protein plays a role in the regulation of both apoptosis and the cell cycle.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18179

code

C18179

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

Contributing_Source

CTRP

DEFINITION

Baculoviral IAP repeat-containing protein 5 (142 aa, ~16 kDa) is encoded by the human BIRC5 gene. This protein plays a role in the regulation of both apoptosis and the cell cycle.

DesignNote

Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. It is abundantly expressed in various human cancers but undetectable in normal differentiated tissues. Survivin associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. It is physically associated with cyclin-dependent kinase p34(cdc2) on the mitotic apparatus, and is phosphorylated on Thr(34) by p34(cdc2)-cyclin B1 in vitro and in vivo. Therefore, survivin phosphorylation on Thr(34) may be required to preserve cell viability at cell division. Manipulation of this pathway may facilitate the elimination of cancer cells at mitosis. (from LocusLink)

Display_Name

Baculoviral IAP Repeat-Containing Protein 5

FULL_SYN

Apoptosis Inhibitor Survivin

Baculoviral IAP Repeat-Containing 5 (Survivin)

Baculoviral IAP Repeat-Containing Protein 5

Apoptosis Inhibitor 4

API4

BIRC5

EPR-1

IAP4

Survivin

label

Baculoviral IAP Repeat-Containing Protein 5

Legacy Concept Name

Survivin

OMIM_Number

603352

Preferred_Name

Baculoviral IAP Repeat-Containing Protein 5

prefixIRI

Thesaurus:C18179

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

O15392

UMLS_CUI

C1571495

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19928

Delete Subject Author Type Created
No notes to display