loading...| Preferred Name |
Samarium Sm-153 |
|
| Synonyms |
Samarium, Isotope of Mass 153 Samarium-153 SAMARIUM SM-153 samarium 153 Samarium Sm-153 153Sm Sm-153 |
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| Definitions |
A beta- and gamma-emitting isotope, with antineoplastic activity. Emitted by samarium Sm 153, beta particles directly damage cellular DNA and, by ionizing intracellular water to produce several types of cytotoxic free radicals and superoxides, indirectly damage intracellular biological macromolecules, resulting in tumor cell death. Samarium Sm 153 also emits gamma-photons that can be detected for external imaging. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1809 |
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| ALT_DEFINITION |
A radioactive substance used in the treatment of bone cancer and bone metastases (cancers that have spread from the original tumor to the bone). Samarium 153 is a radioactive form of the element samarium. It collects in bone, where it releases radiation that may kill cancer cells. It is a type of radioisotope. |
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| CAS_Registry |
15766-00-4 |
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| Chemical_Formula |
Sm |
|
| code |
C1809 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA HemOnc |
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| DEFINITION |
A beta- and gamma-emitting isotope, with antineoplastic activity. Emitted by samarium Sm 153, beta particles directly damage cellular DNA and, by ionizing intracellular water to produce several types of cytotoxic free radicals and superoxides, indirectly damage intracellular biological macromolecules, resulting in tumor cell death. Samarium Sm 153 also emits gamma-photons that can be detected for external imaging. |
|
| FDA_UNII_Code |
6Q1KA41UWM |
|
| FULL_SYN |
Samarium, Isotope of Mass 153 Samarium-153 SAMARIUM SM-153 samarium 153 Samarium Sm-153 153Sm Sm-153 |
|
| label |
Samarium Sm-153 |
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| Legacy Concept Name |
Samarium_153 |
|
| Preferred_Name |
Samarium Sm-153 |
|
| prefixIRI |
Thesaurus:C1809 |
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| Semantic_Type |
Element, Ion, or Isotope Indicator, Reagent, or Diagnostic Aid |
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| UMLS_CUI |
C0677942 |
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| subClassOf |