loading...| Preferred Name | Furin | |
| Synonyms |
Furin Preproprotein Dibasic-Processing Enzyme Paired Basic Amino Acid Residue-Cleaving Enzyme PACE Protein Paired Basic Amino Acid Cleaving Enzyme EC 3.4.21.75 FURIN Furin PACE |
|
| Definitions |
Furin (794 aa, ~87 kDa) is encoded by the human FURIN gene. This protein is involved in endopeptidase activity and the secretory pathway. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17902 |
|
| code |
C17902 |
|
| Concept_In_Subset | ||
| DEFINITION |
Furin (794 aa, ~87 kDa) is encoded by the human FURIN gene. This protein is involved in endopeptidase activity and the secretory pathway. |
|
| DesignNote |
Furin is synthesized as a proenzyme that contains an autoinhibitory peptide sequence. This inhibitory peptide domain must be proteolytically processed twice to generate the active furin molecule. The first cleavage occurs autocatalytically in the endoplasmic reticulum but the inhibitory peptide remains bound until the second cleavage occurs in the trans-Golgi network. (UniProt) Furin cleaves protein substrates at RX(K/R)R consensus motifs. |
|
| FULL_SYN |
Furin Preproprotein Dibasic-Processing Enzyme Paired Basic Amino Acid Residue-Cleaving Enzyme PACE Protein Paired Basic Amino Acid Cleaving Enzyme EC 3.4.21.75 FURIN Furin PACE |
|
| label |
Furin |
|
| Legacy Concept Name |
Furin_Preproprotein |
|
| OMIM_Number |
136950 |
|
| Preferred_Name |
Furin |
|
| prefixIRI |
Thesaurus:C17902 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme |
|
| Swiss_Prot |
P09958 |
|
| UMLS_CUI |
C1310542 |
|
| subClassOf |