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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1782
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1782
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|---|---|
| Preferred Name | Omapatrilat |
| Definitions |
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation.
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| Synonyms |
OMAPATRILAT
Omapatrilat
(4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid
BMS-186716-01
Omapatrilate
BMS-186716
Vanlev
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Omapatrilat
|
|---|---|
| Legacy Concept Name |
Omapatrilat
|
| Preferred_Name |
Omapatrilat
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C1782
|
| DEFINITION |
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation.
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| UMLS_CUI |
C0663645
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| code |
C1782
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| Chemical_Formula |
C19H24N2O4S2
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| subClassOf | |
| type | |
| CAS_Registry |
167305-00-2
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| FULL_SYN |
OMAPATRILAT
Omapatrilat
(4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid
BMS-186716-01
Omapatrilate
BMS-186716
Vanlev
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| FDA_UNII_Code |
36NLI90E7T
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| Contributing_Source |
FDA
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| Concept_In_Subset |
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