Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 | |
| Synonyms |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 MAP Kinase Kinase 1 ERK Activator Kinase 1 MAPK/ERK Kinase 1 Mitogen-Activated Protein Kinase Kinase-1 MAP2K1 Protein EC 2.7.12.2 MAP2K1 MAPKK 1 MEK 1 MEK-1 MKK1 |
|
| Definitions |
Dual specificity mitogen-activated protein kinase kinase 1 (393 aa, ~43 kDa) is encoded by the human MAP2K1 gene. This protein plays a role in protein phosphorylation and the MAP kinase signal transduction pathway. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17808 |
|
| code |
C17808
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP
|
|
| DEFINITION |
Dual specificity mitogen-activated protein kinase kinase 1 (393 aa, ~43 kDa) is encoded by the human MAP2K1 gene. This protein plays a role in protein phosphorylation and the MAP kinase signal transduction pathway.
|
|
| DesignNote |
A component of the RAS intracellular signaling pathway, MAP2K1 is a critical activating protein kinase of MAP kinase. p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway. (Yu et al. Curr Biol 1998. 8:56-64 and OMIMI)
|
|
| Display_Name |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
|
|
| FULL_SYN |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 MAP Kinase Kinase 1 ERK Activator Kinase 1 MAPK/ERK Kinase 1 Mitogen-Activated Protein Kinase Kinase-1 MAP2K1 Protein EC 2.7.12.2 MAP2K1 MAPKK 1 MEK 1 MEK-1 MKK1
|
|
| label |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
|
|
| Legacy Concept Name |
MAP2K1_Protein
|
|
| OMIM_Number |
176872
|
|
| Preferred_Name |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
|
|
| prefixIRI |
Thesaurus:C17808
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
|
|
| Swiss_Prot |
Q02750
|
|
| UMLS_CUI |
C1434639
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping