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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Mitogen-Activated Protein Kinase 8 | |
| Synonyms |
Stress-Activated Protein Kinase 1 JNK1 Protein Stress-Activated Protein Kinase JNK1 Stress-Activated Protein Kinase 1c c-JUN N-Terminal Kinase MAP Kinase 8 Mitogen-Activated Protein Kinase 8 EC 2.7.11.24 JN Kinase MAPK 8 MAPK8 SAPK/JNK SAPK1 SAPK1/JNK SAPK1c |
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| Definitions |
Mitogen-activated protein kinase 8 (427 aa, ~48 kDa) is encoded by the human MAPK8 gene. This protein plays a role in serine/threonine phosphorylation, apoptosis and toll-like receptor signaling. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17780 |
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| code |
C17780
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| DEFINITION |
Mitogen-activated protein kinase 8 (427 aa, ~48 kDa) is encoded by the human MAPK8 gene. This protein plays a role in serine/threonine phosphorylation, apoptosis and toll-like receptor signaling.
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| DesignNote |
Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells.
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| FULL_SYN |
Stress-Activated Protein Kinase 1 JNK1 Protein Stress-Activated Protein Kinase JNK1 Stress-Activated Protein Kinase 1c c-JUN N-Terminal Kinase MAP Kinase 8 Mitogen-Activated Protein Kinase 8 EC 2.7.11.24 JN Kinase MAPK 8 MAPK8 SAPK/JNK SAPK1 SAPK1/JNK SAPK1c
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| label |
Mitogen-Activated Protein Kinase 8
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| Legacy Concept Name |
MAP-Kinase-8
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| OMIM_Number |
601158
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| Preferred_Name |
Mitogen-Activated Protein Kinase 8
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| prefixIRI |
Thesaurus:C17780
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| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
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| Swiss_Prot |
P45983
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| UMLS_CUI |
C0380051
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| subClassOf |
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