National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cytoplasmic Receptor

Synonyms

Cytoplasmic Receptor

Receptor, Cytoplasmic

Definitions

Cytoplasmic Receptors are selective binding proteins that mediate the physiologic effects of specific bound regulatory molecules, such as hormones that cause a conformational and functional change in the receptor molecule. Interaction of the ligand-bound receptor with target molecules is altered, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. Steroid receptors are cytoplasmic carriers that translocate to the nucleus upon ligand binding and regulate the expression of specific target genes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17670

code

C17670

DEFINITION

Cytoplasmic Receptors are selective binding proteins that mediate the physiologic effects of specific bound regulatory molecules, such as hormones that cause a conformational and functional change in the receptor molecule. Interaction of the ligand-bound receptor with target molecules is altered, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. Steroid receptors are cytoplasmic carriers that translocate to the nucleus upon ligand binding and regulate the expression of specific target genes.

FULL_SYN

Cytoplasmic Receptor

Receptor, Cytoplasmic

label

Cytoplasmic Receptor

Legacy Concept Name

Cytoplasmic_Receptor

Preferred_Name

Cytoplasmic Receptor

prefixIRI

Thesaurus:C17670

Semantic_Type

Amino Acid, Peptide, or Protein

Receptor

UMLS_CUI

C0206587

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20033

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